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Benefits of Segmented Flow Chemistry
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Broader Chemistry Conditions
Segmented flow chemistry systems enable extreme reaction conditions at temperatures of up to 300 °C pressures of up to 150 bar. These conditions are more extreme than typical small scale microwave reactors and they have the added flexibility of scaleability (milligrams to 100s of grams) in the same reactor system. -
Experiment Throughput
Throughput with segmented flow chemistry is dramatically greater than that of continuous flow. Because experiments (segments) are segregated by immiscible solvent, multiple segments can be metered, mixed and injected into the flow reactor in a serial/parallel methodology. Increased throughput can be as much as a factor of 10 times that of continuous flow. -
Reagent Usage
Segmented flow chemistry eliminates the over use of precious and expensive reagents. This is specifically useful when developing new reactions (screening and optimization) as only the minimum required amount of reactant is utilized for each analytical experiment. Unlike continuous flow chemistry the amount of reactant used per experiment is independent of the reactor volume. -
Minimized Diffusion
Segmented flow chemistry uses an immiscible solvent as a spacer that maintains a consistent concentrated segment as it progresses through the flow reactor. The dilution effects observed in continuous flow systems are nonexistent in segment flow chemistry systems. This also enables more consistent sampling of product for online analytical and preparative LC/MS. -
Chemical Compatibility
In segmented flow chemistry, the working components of the system (pumps, syringes, check valves) are never exposed to the reactant materials. Enabling the routine use of harsh reagents such as HCl and H2SO4. -
Online LC/MS
Only Accendo Corporation's segmented flow reactors have online LC/MS interface options. Both analytical and preparative LC/MS are easily integrated. Our analytical interface option even works up the sampled segment by diluting prior to injection into the analytical system.
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