Accendo Corporation's AUTOMATED chemical flow reaction systems utilize a segmented flow technology that enables automated reaction preparation, synthesis and online analysis. Drug discovery and process research scientists have adopted Accendo's technology to expand their chemistry capabilities and dramatically increase laboratory productivity. Our systems have enabled the pursuit of faster, greener and cleaner reactions including:

• Click Chemistries	• Decarboxylations	• Diastereoselective Alkylations
• Suzuki Reactions	• Ullman Couplings	• Sonogashira Couplings
• Decarboxylations	• SNAr Substitutions	• Diels-Alder Reactions
• Cycloadditions	• Brominations	• Claisen Rearrangements
• Michael Additions	• Heck Couplings

The Conjure Flow Reactor System , commercialized in June 2009, is a powerful and highly automated multi-step chemical flow reactor system that automates the screening/optimization and online LC/MS analysis of hundreds of conditions. Once optimized starting materials can be scaled to gram level quantities. Automated synthesis of large and small compound libraries is fast and efficient with the Conjure's 40 reagent carousel.

The Propel Flow Reactor System , introduced in February 2010, is an automated segmented flow reactor that uses the technology developed for the Conjure but designed for a multiple user "WALK UP" environment where ease-of-use is critical. With the Propel, exploring flow reactions is simple and fast, automatically screen up to nine conditions and scale to hundreds of grams. Like the Conjure, the Propel may be optionally configured for automated online LC/MS analysis.

The Conjure and Propel are currently operational in medicinal chemistry and process research performing:

• Reaction Screening	• Optimization	• Scaffold Scale Up
• Library Synthesis	• Route Scouting	• Starting Materials (grams)
• Early Process Research Scaling (100s grams)

Learn more about how segmented flow broadens chemistry space and increases laboratory efficiency Segmented Flow